Protein S (PROS1) Rat Monoclonal Antibody [Clone ID: PS7]

Specifications

Product Data
Clone Name	PS7
Applications	WB
Recommend Dilution	Flow Cytometry: 1/50. Western blot: 1/50.
Reactivity	Human
Host	Rat
Clonality	Monoclonal
Specificity	Monoclonal antibody PS7 is specific for human Protein S (PS), a vitamin K-dependent plasma glycoprotein with a molecular weight of approximately 70 kDa. Allows specific detection of cells carrying PS by flow cytometry.
Isotype	IgG2a
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% BSA Preservative: 0.02% Sodium Azide
Concentration	lot specific
Purification	Affinity Cchromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C.
Gene Name	protein S (alpha)
Database Link	Entrez Gene 5627 Human UniProt ID P07225
Background	In humans, PS is mainly synthesized by hepatocytes. Mature PS has a modular structure consisting of a Gla-domain containing a short aromatic stack, a region sensitive to cleavage by thrombin and factor Xa , 4 epidermal growth factor (EGF)-like domains, and a sex hormone-binding globulin-like region. The biologic function of PS thought to be of primary importance is its ability to enhance Activated Protein C-dependent proteolytic inactivation of factors Va and VIIIa, which are respectively the cofactors in the pro-thrombinase and tenase complexes of the coagulation cascade. In this way, PS plays an important role in regulating thrombin generation, and therefore controlling procoagulant activity. Crucial to the APC-dependent functions of PS is the high-affinity interaction between PS and negatively charged phospholipid surfaces, conferred by calcium-induced folding of the amino-terminal Gla-domain.
Synonyms	PROS
Reference Data

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