CD14 Mouse Monoclonal Antibody [Clone ID: 18D11]

Specifications

Product Data
Clone Name	18D11
Applications	FN
Recommend Dilution	Flow cytometry: Typical starting working dilution is 1:50. Inhibits biological activity of sCD14, it inhibits LPS induced TNF production.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody recognizes human monocyte marker CD14, a 53 kDa glycoprotein, with both soluble and membrane CD14.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	CD14 molecule
Database Link	Entrez Gene 929 Human UniProt ID P08571
Background	CD14 is a glycophosphatidylinositol-linked protein, which is part of the LPS receptor complex. CD14 binds lipopolysaccharide (LPS) and as such, acts as a pattern recognition receptor (PRR). CD14 has also been suggested to mediate phagocytosis of bacteria an apoptotic cells. CD14 is involved in the endotoxin mediated release of Tumor Necrosis Factor-alpha by monocytic cells. CD14 is present on most monocytic and macrophage like cell types: monocytes, macrophages, Kupffer cells, pleural phagocytic cells and dendritic reticular cells. CD14 is present at low density on a subpopulation granulocytes and activated or transformed B-cells.
Synonyms	CD14
Reference Data

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