Afdn (1814-1829) Mouse Monoclonal Antibody [Clone ID: 3]

Specifications

Product Data
Clone Name	3
Applications	ELISA, IP, WB
Recommend Dilution	Immunohistochemistry on frozen sections. Immunoassay. Immunoprecipitation. Western blot: The typical starting working dilution is 1:50. Fixation with PFA or acetone/methanol is recommended.
Reactivity	Canine, Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Peptide 1814-1829 aa of rat l-afadin
Specificity	This antibody detects L-Afadin.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid 0.2 µm filtered Ig fraction Stabilizer: 0.1% bovine serum albumin Preservative: 0.02% sodium azide
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 4
Database Link	Entrez Gene 26955 Rat UniProt ID O35889
Background	Afadin is an actin filament-binding protein that is involved in cell-cell adherens junctions (AJs) which directly interacts with the alpha herpus virus receptor, a member of the immunoglobulin supergene family. Afadin is colocalized with nectin at cadherin-based cell-cell adherence junctions in various tissues and cell lines. L-Afadin has been isolated as an F-actin-binding protein from rat brain. L-afadin is ubiquitously expressed and specifically localized at zonula adherens (ZA) in epithelial cells and at cell-cell adherens junctions (AJs) in non-epithelial cells. L-afadin has a splice variant, named small intestine absorptive afadin (s-afadin) which is abundantly expressed in neural tissue.
Synonyms	Protein AF-6
Reference Data

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