Scarb1 Mouse Monoclonal Antibody [Clone ID: SR-BI]

Specifications

Product Data
Clone Name	SR-BI
Applications	FN, IHC
Recommend Dilution	Flow cytometry (starting working dilution is 1:50). Immunohistochemistry on frozen sections. Functional assays.
Reactivity	Rat
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody reacts with rat class B scavenger receptor type I (SR-BI). It blocks the biological activity of rat SR-BI. For example, it inhibits the ability of SR-BI to mediate the corporation of lipids of HDL by SR-BI expressing cells.
Isotype	IgG1
Formulation	PBS State: Purified State: Liquid purified 0.2 µm filtered Ig fraction Preservative: 0.1% bovine serum albumin
Concentration	lot specific
Purification	Protein G
Conjugation	Unconjugated
Storage Condition	Store at 2 - 8 °C.
Gene Name	scavenger receptor class B, member 1
Database Link	Entrez Gene 25073 Rat UniProt ID P97943
Background	Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense. SR-BI belongs together with CD36 to the class B scavenger receptor family. SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite-modified LDL and more. In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta-amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.
Synonyms	SRB1, SR-BI, CLA1, CLA-1, CD36L1
Reference Data

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