Ferritin Mouse Monoclonal Antibody [Clone ID: mAb 44]

Specifications

Product Data
Clone Name	mAb 44
Applications	ELISA, IHC
Recommend Dilution	Immunohistochemistry on frozen sections: 0.5 μg/ml (1:800). Has been described to work in ELISA. Suggested positive control: Human tonsil.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Ferritin from human spleen and liver
Specificity	This antibody recognizes ferritin.
Isotype	IgG1
Formulation	Stock solution contains 0.4mg/ml IgG, phosphate buffered saline pH 7.2 (PBS), 10mg/ml bovine serum albumin (BSA) as a stabilizer and 0.01% thimerosal as a preservative State: Aff - Purified State: Lyophilized Ig fraction
Reconstitution Method	Reconstitute by adding 0.5ml distilled water.
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at 2-8°C. Following reconstitution store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Background	Ferritin consists of a mineral core of hydrated ferric oxide, and a multi-subunit protein shell which englobes the former and assures its solubility in an aqueous environment. It is mainly localized intracellularly in cells of the reticuloendothelial system as well as in liver, spleen and bone marrow. Elevated serum levels are found in patients with iron overload and in other diseases such as pernicious anaemia, chronic inflammations such as rheumatoid arthritis (RA), hepatocellular carcinoma and Hodgkin’s disease. Ferritin consists of two components, the apoferritin and the iron core (FeIII - hydroxyphosphate-micelle). The apoferritin is a globular protein built up of 24 subunits that can bind up to 4500 iron atoms. Other non-ferrous metal ions such as Al or Be can also bind to ferritin, which acts partly as a metal ion detoxicant.
Synonyms	FTH, FTL, Ferritin H subunit, Ferritin L subunit
Reference Data

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