Cd80 Hamster Monoclonal Antibody [Clone ID: 16-10A1]

Specifications

Product Data
Clone Name	16-10A1
Applications	FC, FN, IHC, IP
Recommend Dilution	Flow Cytometry: 6 μg/ml. Immunoprecipitation. Immunohistochemistry on Frozen Sections. Functional Application: Blocking.
Reactivity	Canine, Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	CD80-transfected CHO cell line
Specificity	This Hamster antibody reacts with CD80 (B7-1), a 60 kDa single chain type I glycoprotein of immunoglobulin supergene family, expressed on professional antigen-presenting cells, such as dendritic cells, macrophages or activated B lymphocytes.
Formulation	Phosphate buffered saline (PBS), pH~7.4 with 15 mM Sodium Azide State: Aff - Purified State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein-A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C for up to one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	CD80 antigen
Database Link	Entrez Gene 12519 Mouse UniProt ID Q00609
Background	CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation, the both molecules can also substitute for each other in this process. The question what are the differences in CD80 and CD86 competency has not been fully elucidated yet; there are still conflicts in results about their respective roles in initiation or sustaining of the T cell immune response.
Synonyms	CD28LG, CD28LG1, LAB7, BB1, B7.1, B7-1
Reference Data

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.