Ferritin (heavy and light chain), (Spleen) Mouse Monoclonal Antibody [Clone ID: 090-12710]

Specifications

Product Data
Clone Name	090-12710
Applications	ELISA
Recommend Dilution	ELISA. Recommended Pairs for Sandwich Immunoassay Capture / Detection: AM24001PU-N / AM00837PU-N AM24001PU-N / AM00840PU-N AM24001PU-N / AM00838PU-N AM00839PU-N / AM24001PU-N
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Ferritin from Human Spleen.
Specificity	Recognizes Human Ferritin (Spleen)
Isotype	IgG1
Formulation	10 mM Phosphate, pH 7.4 containing 150 mM Sodium Chloride State: Purified State: Liquid purified IgG fraction (>90% pure by SDS-PAGE) Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Protein A Chromatography. Product is 0.2 µm filtered.
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	Ferritin is a ubiquitous and highly conserved protein which plays a major role in iron homeostasis by sequestering and storing iron in a non-toxic and soluble form. It forms a holoenzyme of ~450 kDa, consisting of 24 subunits of two types, H (heavy; 21 kDa) and L (light; 19 kDa), and is capable of storing up to 4,500 atoms of ferric iron. Depending on the tissue type and physiological status of the cell, the ratio of H to L subunits in ferritin can vary widely. Ferritin is found in the liver, spleen, kidney and heart, with smaller amounts being found in blood. Serum ferritin levels serve as an indicator of the amount of iron stored in the body. Serum ferritin is the most sensitive test for anaemia, and is also used as a marker for restless leg syndrome, hemochromatosis and porphyria. As ferritin is an acute-phase reactant, it is often elevated during infection. Defects in ferritin proteins are associated with several neurodegenerative diseases.
Synonyms	FTH, FTL, Ferritin H subunit, Ferritin L subunit
Reference Data

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