HEPC (HAMP) (25-85) Mouse Monoclonal Antibody [Clone ID: 1F9]

Specifications

Product Data
Clone Name	1F9
Applications	ELISA, IHC, WB
Recommend Dilution	ELISA. Immunohistochemistry on Paraffin Sections: 5 µg/ml. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	HAMP (AAH20612, 25 a.a. ~ 85 a.a) full length recombinant protein with GST tag.
Specificity	This antibody recognizes Hepcidin Antimicrobial Peptide (HAMP) aa 25-85.
Formulation	PBS, pH 7.4 State: Liquid purified Ig fraction
Concentration	lot specific
Purification	Protein A Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store undiluted (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	hepcidin antimicrobial peptide
Database Link	Entrez Gene 57817 Human UniProt ID P81172
Background	Hepcidin, an human antimicrobial peptide, contains a leader sequence, a proteolysis site and a C-terminal 25 amino acid active peptide. This peptide is most active against gram-positive bacteria, but also inhibits the growth of certain yeast and gram-negative bacteria. HAMP also functions as a signaling molecule involved in the maintenance of iron homeostasis. In conjugation with HFE it seems to regulate both intestinal iron absorption and iron storage in macrophages. Mutations in HAMP are found in juvenile hemochromatosis.
Synonyms	LEAP-1, HEPC, LEAP1, PLTR
Reference Data
Protein Families	Secreted Protein, Transmembrane

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