NFH (NEFH) (Phospho and non-Phospho) Mouse Monoclonal Antibody [Clone ID: NF-200]

Specifications

Product Data
Clone Name	NF-200
Applications	IHC, WB
Recommend Dilution	Western Blot: 0.5 µg/ml. Immunohistochemistry on frozen and paraffin sections: 1 - 2 μg/ml.
Reactivity	Human, Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	C-terminal segment of enzymatically dephosphorylated pig Neurofilament 200.
Specificity	This antibody reacts to Neurofilament H (200 kD).
Formulation	1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative. State: Purified State: Lyphilized purified Ig fraction
Reconstitution Method	Restore with 1.2% sodium acetate or neutral PBS
Concentration	0,1 mg/ml (after reconstitution with PBS)
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store at -20°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	neurofilament, heavy polypeptide
Database Link	Entrez Gene 24587 RatEntrez Gene 380684 MouseEntrez Gene 4744 Human UniProt ID P12036
Background	Neurofilaments are composed of 3 neuron-specific proteins with apparent molecular masses of 68 Kd (NFL), 125 kD (NFM), and 200 kD (NFH) on SDS-gel electrophoresis. Genomic clones for the largest human neurofilament protein (NF-H) were isolated, the intron/exon boundaries mapped and the entire protein-coding regions (exons) sequenced. mutations in neurofilaments have been linked to some forms of Charcot-Marie-Tooth disease (CMT)
Synonyms	NEFH,NF-H,KIAA0845, NFH, 200 kDa neurofilament protein, Neurofilament triplet H protein, (Neuronal Marker), heavy polypeptide
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Amyotrophic lateral sclerosis (ALS)

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