CCR5 Mouse Monoclonal Antibody [Clone ID: T21/8]

Specifications

Product Data
Clone Name	T21/8
Applications	ELISA, FC, IHC, IP, WB
Recommend Dilution	ELISA. Flow Cytometry: This T21/8 (T21/8) antibody has been tested by Flow cytometric analysis of normal human peripheral blood cells. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µl. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Immunohistochemistry on Paraffin Sections: 20 µg/ml. Immunoprecipitation. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human CCR5
Specificity	Recognizes C-C Chemokine Receptor 5 (CCR5).
Isotype	IgG1
Formulation	Aqeous buffer containing 0.09% Sodium Azide as preservative and may contain carrier protein/stabilizer State: Aff - Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	C-C motif chemokine receptor 5 (gene/pseudogene)
Database Link	Entrez Gene 1234 Human UniProt ID P51681
Background	Human CD195 is a member of the G protein coupled superfamily of receptors, which acts as a receptor for a number of chemokines including RANTES and also serves as a co-receptor for the entry of HIV into cells. It plays a key role in regulating the activation and migration of leukocytes. CD195 is expressed by a subset of T lymphocytes and by monocytes. CD195 is rapidly phosphorylated within the C-terminal domain upon ligand stimulation. Recent studies suggest that phosphorylation at Ser337 is mediated by Protein kinase C, whereas phosphorylation at Ser349 is mediated by GPCR kinases.
Synonyms	C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, CMKBR5, CHEMR13
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, GPCR, Transmembrane
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis

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