CRMP2 (DPYSL2) Mouse Monoclonal Antibody [Clone ID: 33CT11.40.3]

Specifications

Product Data
Clone Name	33CT11.40.3
Applications	IHC, WB
Recommend Dilution	ELISA: 1/1,000. Western blotting: 1/500-1/1000. Immunohistochemistry on Paraffin Sections: 1/200.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant DHP fusion protein.
Specificity	This antibody is specific to DRP-2.
Isotype	IgG2b
Formulation	State: Ascites State: Ascites containing 0.09% (W/V) Sodium Azide as preservative.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	dihydropyrimidinase like 2
Database Link	Entrez Gene 1808 Human UniProt ID Q16555
Background	DRP-2, also known as collapsin response mediator protein-2 (CRMP-2), is expressed at high levels in the developing nervous system and plays a critical role in axonal outgrowth by specifying axon/dendrite fate and establishing neuronal polarity (1,2). CRMP-2 enhances axon elongation and branching by binding to tubulin heterodimers to promote microtubule assembly (3). GSK-3β inactivates CRMP-2 by phosphorylating it at Thr514. CRMP-2 is primed following phosphorylation at Ser522 by CDK5 and at Thr518 by GSK-3β (2). Phosphorylation of CRMP-2, which decreases tubulin binding ability, can be inhibited by NT-3 and BDNF through the PI3 kinase/Akt pathway (2). CRMP-2 also mediates semaphorin-induced growth cone collapse (4). Hyperphosphorylation of CRMP-2 and is found in Alzheimer disease plaques with concurrent elevated GSK-3β activity in these patients (5).
Synonyms	Dihydropyrimidinase-related protein 2, DRP-2, N2A3
Reference Data

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