HES1 Mouse Monoclonal Antibody [Clone ID: 7C2g2]

Specifications

Product Data
Clone Name	7C2g2
Applications	ELISA, WB
Recommend Dilution	ELISA: 1/20000-1/100000. Western Blot: 1/2000-1/10000. Immunohistochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide derived from C terminal part of HES-1 protein
Specificity	Reacts with Human 30kDa HES-1 protein. May cross react with Mouse and Rat.
Isotype	IgG1
Formulation	0.1M Tris, 0.1M Glycine and 2% Sucrose State: Purified State: Lyophilized purified powder Preservative: None
Reconstitution Method	Restore in distilled water.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Prior to reconstitution store the antibody at -20°C. Store reconstituted antibody at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	hes family bHLH transcription factor 1
Database Link	Entrez Gene 3280 Human UniProt ID Q14469
Background	HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.
Synonyms	HES-1, HL, HRY, Hairy-like, HHL, Hairy homolog
Reference Data

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