Nitrotyrosine Mouse Monoclonal Antibody [Clone ID: 11C2]

Specifications

Product Data
Clone Name	11C2
Applications	ELISA, IF, IHC, WB
Recommend Dilution	ELISA: 1/100-1/1000. Western Blot: 1/100-1/500. Immunocytochemistry: 1/100-1/500. Immunohistochemistry: 1/100-1/500.
Host	Mouse
Clonality	Monoclonal
Immunogen	KLH-Nitrotyrosine
Specificity	Reacts with free and bound Nitrotyrosine. No cross reaction with free or bound Tyrosine
Isotype	IgG1
Formulation	State: Supernatant State: Lyophilized Cell Culture Supernatant Preservative: 0.02% Sodium Azide
Reconstitution Method	Restore in distilled water.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Background	The enzymatic conversion of arginine to citrulline by nitric oxide synthase (NO Synthase) leads to the formation of nitric oxide (NO). NO forms peroxynitrite following the reaction with superoxide. Peroxynitrite is a potent oxidant that reacts with a variety of biological molecules, including tyrosine residues in proteins. Tyrosine nitration can inactivate enzymes and receptors that depend on tyrosine residues for their activity. Nitration prevents phosphorylation of tyrosnine residues important for signal transduction.
Synonyms	NO-Tyrosine, Nitro-Tyrosine
Reference Data

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