Bcl-2 Mouse Monoclonal Antibody [Clone ID: 124]

Specifications

Product Data
Clone Name	124
Applications	IHC, WB
Recommend Dilution	Western blot. Immunohistochemistry on Formalin-Fixed, Paraffin-Embedded Sections: 1/100-1/200 Pretreatment of deperaffinized tissue with heat-induced epitope retrieval is recommended. Use Polymer anti Mouse/Rabbit IgG as a detection system. Positive Control: Tonsil or lymph node.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A synthetic peptide corresponduing to amino acids 41-54 of Human Bcl-2 protein.
Specificity	This antibody is specific to bcl-2 oncoprotein encoded by a gene involved in the 14; 18 chromosomal translocation. Cellular Localization: Cytoplasmic.
Isotype	IgG1
Formulation	State: Supernatant State: Liquid Tissue Culture Supernatant with 0.2% BSA and 15mM Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	B cell leukemia/lymphoma 2
Database Link	UniProt ID P10417
Background	Bcl-2 protein family members function either to promote or inhibit programmed cell death. Some of these proteins, such as Bax and Bak, function to promote apoptosis, whereas others like Bcl-2 and Bcl-XL inhibit apoptosis. Bcl-2, typically an inhibitor of apoptosis, has also been demonstrated to have pro-apoptotic activity. The Bcl-2 protein is a suppressor of apoptosis that homodimerizes with itself and forms heterodimers with Bax. Expression of Bcl-2α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of Bcl-2α protein, whereas the normal or hyperplastic germinal centers are negative.
Synonyms	BCL2, Bcl-2 alpha
Reference Data

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