CA 19-9 Mouse Monoclonal Antibody [Clone ID: SLA203]

Specifications

Product Data
Clone Name	SLA203
Applications	IHC
Recommend Dilution	Suitable for Immunohistochemistry and Immunocytochemistry (Frozen or Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections and cell smears). For IHC dilute concentared antibody at 1/50-1/100, use streptavidin~biotin system or polymer system, incubate 30 minutes at room temperature. FFPE tissue section requires antigen retriever (boiling tissue in 10 mM citrate, pH 6.0 for 20 mins, followed by cooling at RT for 20 mins). Recommended Positive Control: Human colon, stomach, pancreas, intestine, breast carcinomas.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Mucins from ovarian cyst.
Specificity	This antibody reacts with CA 19-9 antigen. Does not cross react with CA125, CA15-3, CEA. Cellular localization: Cytoplasmic.
Isotype	IgG1
Formulation	PBS, pH 7.4 containing 1% BSA as stabilizer and 0.05% Sodium Azide as preservative. State: Purified State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Background	The CA 19-9 antigen is a monosialosyl Le (a) blood group antigen which has been shown to be a useful-associated antigen for the diagnosis of gastrointestinal cancers. This antigen is known to be a ligand for the cell adhesion molecule called ELAM-1 (E-selectin, endothelial cell leukocyte adhesion molecule-1, which is present on cytokine-activated human endothelial cells. Selectin GMP-140 (CD62;PADGEM) binds to sialosyl Le (a) and sulfated glycans modulate this binding.
Synonyms	CA19-9, Sialosyl Lewis a, Sialyl Lewis a
Reference Data

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