AKR1C1 (1-323) Mouse Monoclonal Antibody [Clone ID: AT6D10]

Specifications

Product Data
Clone Name	AT6D10
Applications	ELISA, FACS, FC, ICC/IF, IF, IHC, WB
Recommend Dilution	ELISA. Western blot: 1/1000. Immunohistochemistry on Paraffin Sections: 10 µg/ml. Immunocytochemistry / Immunoflourescence. Flow cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human AKR1C1 (1-323aa) purified from E. coli
Specificity	The antibody recognizes Human AKR1C1 at aa 1-323.
Isotype	IgG1, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	aldo-keto reductase family 1, member C1
Database Link	NP_001344 Entrez Gene 1645 Human UniProt ID Q04828
Background	The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) have major roles in pre receptor regulation of progesterone action. They can both convert progesterone to the less potent efficiencies. AKR1C1 and AKR1C3 also act as 3-ketosteroid reductase, and as such they can convert the most potent androgen 5alpha-DHT into 3beta-andorstandiol, which is an estrogen receptor beta ligand, and into the inactive androgen 3alpha-androstnionl, respectively.
Synonyms	Aldo-keto reductase family 1 member C1, DDH1, DDH, MBAB, DD1, HAKRC, Dihydrodiol dehydrogenase 1, 20-alpha (3-alpha)-hydroxysteroid dehydrogenase, High-affinity hepatic bile acid-binding protein (HBAB)
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Metabolism of xenobiotics by cytochrome P450

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