FPRL1 (FPR2) (C-term) Mouse Monoclonal Antibody [Clone ID: B4D9B10]

Specifications

Product Data
Clone Name	B4D9B10
Applications	ELISA, WB
Recommend Dilution	ELISA: Reactive to the C-terminal amino acid sequence (SASPPAETELQAM) on FPRL1 in Indirect ELISA. Western Blot (1/1000).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A short peptide corresponding to the Cterminal amino acid sequence (SASPPAETELQAM) on FPRL1
Specificity	This monoclonal antibody reacts with the above mentioned peptide in ELISA and reacts with the 38KDa FPRL1 on Western Blot.
Isotype	IgG1
Formulation	0.01M PBS, pH 7.2 without preservatives State: Purified State: Lyophilized purified IgG fraction
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Upon receipt, store (in aliquots) at -20°C. Avoid repeated freezing and thawing.
Gene Name	formyl peptide receptor 2
Database Link	Entrez Gene 2358 Human UniProt ID P25090
Background	FPRL1 is a low affinity receptor to N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4). FPRL1 has been reported in phagocytes, monocytes, neutrophils, differentiated myeloid cells from bone marrow, granulocyte HL-60 cells, and synovial fibroblasts. ESTs have been isolated from blood, leukocyte, lung, and placenta libraries.
Synonyms	N-formyl peptide receptor 2, FMLP-R-I, FPRH1, RFP, LXA4R
Reference Data
Protein Families	Druggable Genome, GPCR, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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