Protein C (PROC) Mouse Monoclonal Antibody [Clone ID: HLW-C]

Specifications

Product Data
Clone Name	HLW-C
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human Protein C derived from Human blood.
Specificity	Human Protein C.
Isotype	IgG2b
Formulation	0.01M PBS, pH 7.2 without preservatives. State: Aff - Purified State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	protein C, inactivator of coagulation factors Va and VIIIa
Database Link	Entrez Gene 5624 Human UniProt ID P04070
Background	Protein C is a vitamin K dependent serine protease zymogen. Purified human activated protein C selectively destroys factors Va and VIII:C in human plasma and thus has an important anticoagulant role. Protein C deficiency has been associated with inherited thrombophilia. In its primary structure, protein C is similar to the prothrombin group of blood coagulation factors. It most closely resembles factor X. Protein C is synthesized as a single chain; this precursor molecule is cleaved into a light chain and a heavy chain held together by a disulfide bond. The enzyme is then activated by thrombin, which cleaves a tetradecapeptide from the amino end of the heavy chain.
Synonyms	Vitamin K-dependent protein C, Anticoagulant protein C, PROC1, Autoprothrombin IIA, Blood coagulation factor XIV
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Complement and coagulation cascades

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