CD41-CD61 Complex Mouse Monoclonal Antibody [Clone ID: 237]

Specifications

Product Data
Clone Name	237
Applications	ELISA, WB
Recommend Dilution	This GPIIb/IIIa antibody is Suitable for use in ELISA and Western Blot. Use of this Monoclonal antibody at a concentration of 10-20 µg/ml (culture supernatants) will allow visualization of NP 40 solubilized human normal platelets. The titer of purified ascites was determined by ELISA coated with 100 µl of 1x108 washed platelets.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	10e9 Human platelets suspension. The supernatant fluid from positive clones was screened by ELISA coated with washed platelets.
Specificity	Human platelet membrane glycoproteins IIb/IIIa (GP IIb/IIIa). Under reducing conditions, this antibody will bind against the Human platelet membrane glycoproteins IIb/IIIa complex, which have a molecular weights of ~130,000 (IIb) and 115,000 (IIIa).
Isotype	IgG1
Formulation	0.01M PBS, pH 7.2 without preservatives. State: Aff - Purified State: Lyophilized purified IgG fraction.
Reconstitution Method	Restore with Double distillated water to adjust the final concentration to 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Background	The integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated alpha and beta subunits. CD61 non-covalently associates with CD41 (alpha Ilb integrin) and is expressed by megakaryocytes and platelets. The CD61/CD41 complex acts as a receptor for such adhesive ligands as fibronectin, fibrinogen and von Willebrand factor during platelet stimulation.
Synonyms	GPIIb-IIIa, ITGA2B, GP2B, ITGAB, Platelet membrane glycoprotein IIb, GPalpha IIb, GPIIb, GP3A, CD41, CD61, Integrin alpha-IIb, Integrin beta-3, ITGB3
Reference Data

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