PML Protein (PML) Mouse Monoclonal Antibody [Clone ID: B4C8]

Specifications

Product Data
Clone Name	B4C8
Applications	WB
Recommend Dilution	EIA. Western Blot: A106Kd band was observed in K562 cell extract in Western blotting experiment. The K562 cells express the high molecular weight PML/RARa chimera.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant partial human PML
Specificity	This antibody recognizes normal PML proteins of lower molecular weight, and also recognizes the high molecular weight PML/RARα chimeric protein in promyelocytic leukemia patients.
Isotype	IgG1
Formulation	0.01M PBS, pH 7.4 State: Aff - Purified State: Lyophilized purified Ig fraction
Reconstitution Method	Restore in appropriate volume of distilled H2O to reach a final antibody concentration of 1.0 mg/ml.
Purification	Affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Gene Name	promyelocytic leukemia
Database Link	Entrez Gene 5371 Human UniProt ID P29590
Background	PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.
Synonyms	RING finger protein 71, MYL, TRIM19
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis

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