PML Protein (PML) Mouse Monoclonal Antibody [Clone ID: B3E9]

Specifications

Product Data
Clone Name	B3E9
Applications	WB
Recommend Dilution	Western Blot: Use PML antibody at 1/2,000 dilution to differentiate normal PML and Chimeric PML/RAR alpha molecules based on their molecular weight.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant partial Human PML.
Specificity	This antibody recognizes normal PML proteins of lower Molecular Weight, and also recognizes the High Molecular Weight PML/RAR-alpha Chimeric protein in promyelocytic leukemia patients.
Isotype	IgG1
Formulation	0.01M PBS, pH 7.4 without preservatives. State: Aff - Purified State: Lyophilized purified Ig fraction.
Reconstitution Method	Restore by adding appropriate volume of distilled water to reach a final antibody concentration of 1.0 mg/ml.
Purification	Affinity Chromatography on Protein G.
Conjugation	Unconjugated
Storage Condition	Store the antibody (in aliquots) at -20°C. After reconstitution, aliquot and store at -20°C.
Gene Name	promyelocytic leukemia
Database Link	Entrez Gene 5371 Human UniProt ID P29590
Background	PML is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals.
Synonyms	RING finger protein 71, MYL, TRIM19
Reference Data
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	Acute myeloid leukemia, Pathways in cancer, Ubiquitin mediated proteolysis

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