Cytokeratin 18 (KRT18) (Multi-Epitope Cocktail) Mouse Monoclonal Antibody [Clone ID: Ks18.04/18.27/18.5/9B1/18.174]

Specifications

Product Data
Clone Name	Ks18.04/18.27/18.5/9B1/18.174
Applications	IHC, WB
Recommend Dilution	Immunoblotting (Western). Immunohistochemistry on Frozen and paraffin-Embedded Tissue (only when using the microwave method) and Cytological Material. Working Dilution: Ready-to-use for Immunohistochemistry. Incubation Time: 1h at RT, extended with paraffin sections (over night at 2-8°C).
Reactivity	Bovine, Canine, Fish, Hamster, Human, Mammalian, Mouse, Porcine, Rat, Sheep
Host	Mouse
Clonality	Monoclonal
Immunogen	Keratin K18 of Human and Bovine origin.
Specificity	The antibody cocktail represents an excellent marker to discriminate simple epithelia from those of different origin. Tumors Specifically Detected: all adenocarcinoma; mammary carcinoma, urinary bladder carcinoma, undifferentiated carcinoma, cervix carcinoma, hepatocellular carcinoma. Polypeptide Reacting: Mr 45 000 polypeptide (human and bovine K18; formerly also designated cytokeratin 18) of all simple type epithelia and basal cells of many squamous, nonepidermal epithelia. Reactivities on Cultured Cell Lines: HeLa and MCF-7.
Isotype	IgG1
Formulation	State: Supernatant State: Hybridoma Culture Supernatant Preservative: 0.09% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	keratin 18
Database Link	Entrez Gene 16668 MouseEntrez Gene 294853 RatEntrez Gene 3875 Human UniProt ID P05783
Background	Cytokeratin 18 is an acidic keratin which is found primarily in non-squamous epithelia and is present in a majority of adenocarcinomas and ductal carcinomas but not in squamous cell carcinomas. Cytokeratin 18 exists in combination with Cytokeratin 8, a basic keratin. Hepatocellular carcinomas express only Cytokeratins 8 and 18.
Synonyms	Cytokeratin-18, CK18, Keratin-18, Keratin 18, KRT18, CYK18, K18
Reference Data
Protein Pathways	Pathogenic Escherichia coli infection

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