TDP43 (TARDBP) Mouse Monoclonal Antibody [Clone ID: k1B8]

Specifications

Product Data
Clone Name	k1B8
Applications	ELISA, FACS, IHC, WB
Recommend Dilution	ELISA. Western blot (1/1,000-1/2,000). Flow Cytometry. Immunohistochemistry on Paraffin Sections (1/50-1/100).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human TARDBP (1-260aa) purified from E. coli
Specificity	The antibody recognizes Human TARDBP. Other species not tested.
Isotype	IgG1, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	TAR DNA binding protein
Database Link	NP_031401 Entrez Gene 23435 Human UniProt ID Q13148
Background	TAR DNA binding protein (TARDBP), also known as TDP-43, is a cellular protein. TARDBP was identified as the disease accumulating protein in patients with frontotemporal lobar degeneration (FTLD) with ubiquitin inclusions (FTLD-U) and in amyotrophic lateral sclerosis (ALS). TARDBP functions as a DNA-binding protein and specifically binds to the TAR DNA sequence motifs of HIV. Via this association with TAR motifs, TARDBP acts as a transcriptional repressor and inhibits HIV-1 transcription. In addition, this protein regulates alternate splicing of the cystic fibrosis transmembrane receptor (CFTR) gene.
Synonyms	TAR DNA binding protein, TDP-43, ALS10, TAR DNA-binding protein 43, TDP43
Reference Data
Protein Families	Transcription Factors

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