CD40 Mouse Monoclonal Antibody [Clone ID: HB14]

Specifications

Product Data
Clone Name	HB14
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: 0.5 µg/10E6 cells. Immunohistochemistry on Paraffin Sections: 10 µg/ml.
Reactivity	Human, Monkey
Host	Mouse
Clonality	Monoclonal
Immunogen	Human B cell line
Specificity	This antibody recognizes TNFRSF5/CD40.
Isotype	IgG1
Formulation	PBS, pH 7.2 State: Aff - Purified State: Liquid purified Ig fraction Preservative: 0.09% Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C.
Gene Name	CD40 molecule
Database Link	Entrez Gene 958 Human UniProt ID P25942
Background	CD40 (48 to 50 kDa) is a transmembrane glycoprotein mainly expressed on the surface of B cells and also expressed on monocytes, dendritic cells, and thymic epithelium. CD40 is a member of the tumor necrosis factor (TNF) receptor superfamily, which includes the low affinity nerve growth factor (NGF) receptor and CD95/Fas. CD40 is the receptor for CD40 ligand. CD40 ligand (CD40L, CD154, gp39, and TRAM) belongs to the TNF gene family and is expressed more widely than CD40 predominantly on activated CD4+ T cells. Following interaction with CD40 ligand, CD40 mediates a number of major immunoregulatory functions, central to the control of thymus dependent humoral immunity and may be critical in the development of cell mediated immune responses. Other biological actions include B cell homotypic adhesion, proliferation, immunoglobulin isotype switch, and secretion. Activation of CD40 has also been shown to inhibit the growth of certain B cell lymphomas and to induce the death of transformed cells of mesenchymal or epithelial origin.
Synonyms	TNFRSF5, CDw40, Bp50
Reference Data

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