Cd19 Mouse Monoclonal Antibody [Clone ID: MB19-1]

Specifications

Product Data
Clone Name	MB19-1
Applications	FC, IP
Recommend Dilution	Flow Cytometry: < / = 1 µg/10e6 cells. (Ref.1-3) Immunoprecipitation. (Ref.1)
Reactivity	Mouse
Host	Mouse
Clonality	Monoclonal
Specificity	This antibody is specific to CD19 B cell differentiation antigen (Mr. 95 kDa).
Isotype	IgA
Formulation	PBS containing Sodium Azide as preservative. Label: Biotin State: Liquid purified Ig fraction.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Gene Name	CD19 antigen
Database Link	Entrez Gene 12478 Mouse UniProt ID P25918
Background	CD19 is a monomeric transmembrane glycoprotein expressed at relatively constant levels throughout B cell development from early pro-B/pre-B cells (i.e., B220+/CD43+/HSA+) through fully differentiated B cell stages. (Ref.1-7) Terminally differentiated plasma cells do not express CD19.1 In humans, the CD19 molecule on the surface of mature B cells associates with CD21 (CR-2) and CD81 (TAPA-1), and this multimolecular complex synergizes with surface immunoglobulin to provide signal transduction and promote cellular activation. (Ref.3,4) All splenic and peritoneal IgM+ cells of both B-1 and B-2 lineages are CD19+, with B-1 cells expressing higher levels of CD19 than B-2 cells in these sites. (Ref.1,7) Recent studies with CD19-deficient mice have suggested that this molecule may not be required for normal generation and maturation of B cells in the bone marrow. (Ref.7)
Synonyms	Leu-12, B-cell marker
Reference Data

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