CD18 (ITGB2) Mouse Monoclonal Antibody [Clone ID: 10E12]

Specifications

Product Data
Clone Name	10E12
Applications	ELISA, IF
Recommend Dilution	ELISA: 1/10000. Immunofluorescence: 1/200 - 1/1000.
Reactivity	Human, Mouse
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of CD18 expressed in E. Coli.
Specificity	Recognizes CD18 also known as ITGB2 (integrin beta chain beta 2).
Isotype	IgG2b
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	85 kDa
Gene Name	integrin subunit beta 2
Database Link	Entrez Gene 3689 Human UniProt ID P05107
Background	CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
Synonyms	Integrin beta-2, MFI7
Reference Data

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