SorLA (SORL1) Mouse Monoclonal Antibody [Clone ID: 3B6B11]

Specifications

Product Data
Clone Name	3B6B11
Applications	FC, IF, IHC, WB
Recommend Dilution	ELISA: 1/10000. Western Bloting: 1/500-1/2000. Immunofluorescence: 1/200-1/1000. Immunohistochemistry on Frozen Sections: 1/200-1/1000. Immunohistochemistry on Paraffin Sections: 1/200-1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of Human SORL1 expressed in E. Coli.
Specificity	Recognizes Sortilin-related receptor (SORL1)
Formulation	State: Ascites State: Ascitic fluid Preservative: 0.03% Sodium Azide
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	sortilin-related receptor, L(DLR class) A repeats containing
Database Link	Entrez Gene 6653 Human UniProt ID Q92673
Background	SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
Synonyms	SorLA, SorLA-1, LR11
Reference Data

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