KAT8 Mouse Monoclonal Antibody [Clone ID: 8C4C4]

Specifications

Product Data
Clone Name	8C4C4
Applications	IF, IHC, WB
Recommend Dilution	ELISA: 1/10000. Western Bloting: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000.  Immunohistochemistry on Paraffin Sections: 1/200 - 1/1000.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human MYST1 expressed in E. Coli.
Specificity	Recognizes MYST1
Formulation	State: Ascites State: Ascitic fluid containing 0.03% Sodium Azide.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Predicted Protein Size	53 kDa
Gene Name	lysine acetyltransferase 8
Database Link	Entrez Gene 84148 Human UniProt ID Q9H7Z6
Background	MYST1 (MYST histone acetyltransferase 1, MOF) belongs to the MYST family of histone acetyltransferases, which are employed in the cell to bring about transcriptional regulation. The MYST family includes MYST1, is named for the founding members MOZ, yeast YBF2 and SAS2, and TIP60. All members of this family contain a MYST region of about 240 amino acids with a canonical acetyl-CoA-binding site and a C2HC-type zinc finger motif. Most MYST proteins also have a chromodomain involved in protein- protein interactions and targeting transcriptional regulators to chromatin. Although MOF is expressed in both males and females, it associates with the X chromosome only in males. MOF contains a zinc-finger domain that is used to contact the globular part of the nucleosome and histone H4. The carboxy terminal domain of human MOF also has histone acetyltransferase activity directed against histones H3 and H2A, a characteristic shared with other MYST family histone
Synonyms	MOF, PP7073, YBF2/SAS3, SAS2, TIP60 protein 1, HMOF
Reference Data

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