HLA Class II DQ Mouse Monoclonal Antibody [Clone ID: FN81]

Specifications

Product Data
Clone Name	FN81
Applications	FC, IHC
Recommend Dilution	Immunohistochemistry on Frozen Sections: ≤ 0.2 µg/ml (1/1000). Recommended Positive Control: Human tonsil. Has been described to work in Flow Cytometry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Stimulated human B lymphocytes. The antigen is HLA-DQ. The epitope has not been further characterized.
Specificity	This Monoclonal antibody FN81 recognizes the Human HLA-DQ antigen. Antigen Distribution on Isolated Cells: The HLA DQ antigen is present on approximately 10% of peripheral blood lymphocytes.
Isotype	IgG2a
Formulation	PBS, pH 7.2, with 0.09% Sodium Azide as preservative and 5 mg/ml BSA as stabilizer. State: Aff - Purified State: Lyophilised purified IgG fraction.
Reconstitution Method	Restore with 0.5 ml distilled water (= Stock solution).
Concentration	0.2 mg/ml
Purification	Affinity Chromatography.
Conjugation	Unconjugated
Storage Condition	Store lyophilized at 2-8°C. Stock solution or aliquots of stock solution can be kept frozen at -20°C. Do not freeze working dilutions. Avoid repeated freezing and thawing.
Background	HLA-DQ is an HLA class II antigen with homology to murine H-2A. HLA class II antigens are mainly expressed on specialized antigen presenting cells (APCs), dendritic cells, B-cells and macrophages. HLA class II antigen is presented on activated T-cells. HLA class II molecules present exogenously derived antigen to the T-cell receptor (TCR) on CD4+ T lymphocytes. Both chains in HLA-DQ are polymorphic. HLA-DQ is expressed after DR and DP during haemotopoietic progenitor cell development. It is strongly expressed in the thymic cortex.
Synonyms	MHC Class II DQ
Reference Data

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