CD11c (ITGAX) Mouse Monoclonal Antibody [Clone ID: CBR-p150/4G1]

Specifications

Product Data
Clone Name	CBR-p150/4G1
Applications	FC, FN, IHC
Recommend Dilution	Flow Cytometry. Immunohistochemistry on frozen sections: 5 - 10µg/ml. Functional Assays.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human CD11c
Specificity	This antibody specifically recognises CD11c, otherwise known as integrin alpha X chain and leukocyte adhesion receptor p150,95. Clone CBR-p150/4G1 inhibits the binding of CD11c to endothelial cells. This antibody does not recognise CD11a, CD11b or CD18.
Isotype	IgG2a
Formulation	Phosphate buffered saline State: Azide Free State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	integrin subunit alpha X
Database Link	Entrez Gene 3687 Human UniProt ID P20702
Background	CD11c is a 150kDa type I transmembrane protein and member of the integrin alpha chain family, expressed by monocytes, macrophages, granulocytes and NK cells, and is a marker for hairy cell leukaemia cells. CD11c combines with the CD18 beta chain (ITGB2) to form the leukocyte specific integrin CR4, acts as a mediator of leukocyte adherence to endothelium, and binds to the ligands CD54 (ICAM1), iC3b and fibrinogen.
Synonyms	ITGAX, Integrin alpha-X, Leu M5
Reference Data

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