Complement factor B (CFB) (Bb Fragment) Mouse Monoclonal Antibody [Clone ID: 032B-22.1.X]

Specifications

Product Data
Clone Name	032B-22.1.X
Applications	ELISA, FC, WB
Recommend Dilution	Flow Cytometry. ELISA. Western Blot.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Binds neoantigen of fragment Bb from human complement factor B.
Specificity	This antibody recognises a neoantigen of the Bb fragment of complement factor B.
Isotype	IgG2a
Formulation	Borate buffered saline pH8.2 - 8.4 containing 0.02% Sodium Azide (NaN3) State: Purified State: Liquid purified IgG
Concentration	lot specific
Purification	Affinity chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement factor B
Database Link	Entrez Gene 629 Human UniProt ID P00751
Background	Factor B is present in blood serum. C3b associates with complement factor B, inducing conformational change. This enables complement factor D to cleave the N-terminal of complement factor B (the Ba subunit) leaving the 63 kDa Bb subunit associated with C3b and forming C3 convertase. Subunit Bb is involved in the proliferation of preactivated B lymphocytes. Conversely, Ba inhibits lymphocyte proliferation.
Synonyms	Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD
Reference Data
Protein Families	Druggable Genome, Protease, Secreted Protein
Protein Pathways	Complement and coagulation cascades

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