Cd86 Rat Monoclonal Antibody [Clone ID: PO3]

Specifications

Product Data
Clone Name	PO3
Applications	FC
Recommend Dilution	Flow Cytometry: 1/10.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Mouse B-cell line, BCL1.
Specificity	This antibody recognises CD86 (B7-2). The PO3 clone has been reported to block some co-stimulatory functions of CD86.
Isotype	IgG2b
Formulation	Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide, 1% Bovine Serum Albumin Label: PE State: Lyophilised purified IgG Label: R. Phycoerythrin (RPE)
Reconstitution Method	Reconstitute with 0,25 ml distilled water
Concentration	lot specific
Purification	Affinity chromatography on Protein G
Conjugation	PE
Storage Condition	Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	CD86 antigen
Database Link	Entrez Gene 12524 Mouse UniProt ID P42082
Background	CD86 is an 80kD cell surface glycoprotein which is a member of the CD28/B7 family. In mouse, CD86 is expressed at high levels on peripheral blood monocytes, dendritic cells and at low levels on resting B and T-lymphocytes. Expression of CD86 on these cell populations can be increased upon activation. CD86 has been identified, along with CD80 (B7-1) as a ligand for CD28 and cytotoxic T-lymphocyte antigen-4 (CTLA4). CD28 and CTLA4 are two receptors that have opposing functions in T-cell stimulation. Interaction of CD86 with CD28 promotes a number of T-cell activities, whereas the binding of CD86 to CTLA4 inhibits T-cell responses.
Synonyms	CD28LG2, Activation B7-2 antigen, B70, BU63, B7.2, FUN-1
Reference Data

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