CD51 / ITGAV Rat Monoclonal Antibody [Clone ID: RMV-7]

Specifications

Product Data
Clone Name	RMV-7
Applications	FC, IHC, IP
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/10-1/100 diluted antibody to label 10e6 cells in 100 µl. Immunoprecipitation. Immunohistochemistry on Frozen Sections.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Cultured LAK cells from Balb/c mice.
Specificity	This antibody recognizes CD51. The RMV-7 antibody has been reported to block binding of CD51 to Vitronectin, Fibronectin, and CD31 in some cell types, as well as blocking LAK cell cytotoxicity. We recommend the use of AM05569LE-N for this purpose.
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	integrin alpha V
Database Link	Entrez Gene 16410 Mouse UniProt ID P43406
Background	CD51 is a 140 kD alpha subunit of the vitronectin receptor, which is otherwise known as the intergrin alpha v chain. CD51 can form heterodimers at the cell surface with a variety of beta integrins including CD29 and CD61. Heterodimers of CD51/CD61 functions as a receptor for vitronectin, and a wide array of RGD-containing proteins including fibronectin, fibrinogen, von Willebrand factor, laminin, thrombospondin and osteopontin. CD51/CD61 is primarily expressed on myeloid cells and activated T-cells. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing.
Synonyms	Integrin alpha-V, MSK8, VNRA, Vitronectin receptor subunit alpha
Reference Data

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