Itgax Hamster Monoclonal Antibody [Clone ID: N418]

Specifications

Product Data
Clone Name	N418
Applications	FC
Recommend Dilution	Flow Cytometry: 1/10; use 10µl of the suggested working dilution to label 10e6 cells in 100µl; The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.
Reactivity	Mouse
Host	Hamster
Clonality	Monoclonal
Immunogen	Mouse spleen dendritic cells.
Specificity	This antibody recognises the murine homologue of human CD11c, which is a 150/90kD member of the beta 2 integrin family. In mice, CD11c is primarily expressed by dendritic cells. Clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo.
Isotype	IgG
Formulation	Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide, 1% Bovine Serum Albumin Label: PE State: Lyophilised purified IgG Label: R. Phycoerythrin (RPE)
Reconstitution Method	Reconstitute with 1.0 ml distilled water
Purification	Affinity chromatography on Protein G
Conjugation	PE
Storage Condition	Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Gene Name	integrin alpha X
Database Link	Entrez Gene 16411 Mouse UniProt ID Q9QXH4
Background	CD11c (integrin alpha X chain protein) combines with the beta 2 chain (ITGB2) to form a leukocyte specific integrin referred to as inactivated C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. The CD11c antigen is a marker for hairy cell leukaemia.
Synonyms	ITGAX, Integrin alpha-X, Leu M5
Reference Data

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