Adra2b Mouse Monoclonal Antibody [Clone ID: 5G10]

Specifications

Product Data
Clone Name	5G10
Applications	IHC, WB
Recommend Dilution	Western blot (1-5 µg/ml). Immunohistochemistry. Positive Control/Tissue Expression: MDCK cells transfected with Rat alpha2B adrenergic receptors.
Reactivity	Mouse, Rat
Host	Mouse
Clonality	Monoclonal
Immunogen	Synthetic peptide internal sequence corresponding to the third intracellular loop of Rat alpha 2b Adrenergic Receptor.
Isotype	IgG1
Formulation	PBS containing 0.08% Sodium Azide as preservative. State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody at -20°C. Avoid repeated freezing and thawing.
Gene Name	adrenoceptor alpha 2B
Database Link	Entrez Gene 24174 Rat UniProt ID P19328
Background	The rat alpha 2b adrenergic receptor is a G protein coupled receptor which acts through Gi2 and is responsible for Cellular communication and signal transduction. These receptors are linked to pertussis toxin-sensitive G proteins. Agonist binding leads to inhibition of adenylyl cyclase, inhibition of Ca(2+) channels and activation of K(+) channels. Recently, three distinct subtypes of alpha(2)-AR were described, alpha(2A)-AR, alpha(2B)-AR and alpha(2C)-AR. At present, it is unknown which of these alpha(2)-AR subtype(s) may regulate insulin secretion.
Synonyms	ADRA2L1, ADRA2RL1, Alpha-2B adrenoreceptor, Alpha-2B adrenoceptor
Reference Data

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