PPP1R14A Mouse Monoclonal Antibody [Clone ID: 4H10]

Specifications

Product Data
Clone Name	4H10
Applications	ELISA, ICC/IF, WB
Recommend Dilution	ELISA. Western blot: 1:250 ~ 1:1000 (1:500 as startin dilution).
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant human PPP1R14A (1-147aa) purified from E. coli
Specificity	This antibody detects PPP1R14A.
Isotype	IgG2a, kappa
Formulation	Liquid in. Phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% glycerol
Concentration	1mg/ml (determined by BCA assay)
Purification	By protein-G affinity chromatography
Conjugation	Unconjugated
Storage Condition	Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80C. Avoid repeated freezing and thawing cycles.
Gene Name	protein phosphatase 1 regulatory inhibitor subunit 14A
Database Link	NP_150281 Entrez Gene 94274 Human UniProt ID Q96A00
Background	PPP1R14A (Protein phosphatase 1 regulatory subunit 14A) is a phosphorylation-dependent inhibitory protein for smooth muscle myosin phosphate. Myosin phosphatase can reverse MYL (myosin light chain) phosphorylation to induce a state of relaxation. However, during agonist-induced contraction at constant Ca2+ concurrent inhibition of myosin phosphatase leads to increases in MYL phosphorylation and tension. These calcium-independent increases in myosin phosphorylation and tension are termed calcium sensitization.
Synonyms	Regulatory subunit 14A, Regulatory (inhibitor) subunit 14A CPI 17, Regulatory (inhibitor) subunit 14A, Protein phosphatase 1 regulatory subunit 14A, Protein phosphatase 1 regulatory (inhibitor) subunit 14A, Protein phosphatase 1, PPP1R14A, PPP1INL, PKC potentiated inhibitory protein of PP1, CPI-17, CPI 17 alpha
Reference Data

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