CD147 (BSG) Mouse Monoclonal Antibody [Clone ID: MEM-M6/2]

Specifications

Product Data
Clone Name	MEM-M6/2
Applications	FC, IHC
Recommend Dilution	Flow Cytometry (4 μg/ml). Immunohistochemistry on Paraffin Sections (10 µg/ml).  Positive Control:Testis tissue.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	A soluble recombinant form of CD147, CD147Rg, which consists of the cDNA coding for the entire extracellular region of CD147 fused to the DNA coding for the hinge region, CH2 and CH3 domain of Human IgG1.
Specificity	The antibody MEM-M6/2 recognizes extracellular Ig domain D1 of CD147 (Neurothelin), a 50-60 kDa type I transmembrane glycoprotein primarily expressed on all leukocytes, red blood cells, platelets and endothelial cells; it is not expressed by resting lymphocytes. The antibody MEM-M6/1 is a high-affinity antibody capable of binding to unstimulated peripheral blood T cells.
Formulation	PBS, pH~7.4 State: Aff - Purified State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE) Preservative: 15 mM Sodium Azide
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	basigin (Ok blood group)
Database Link	Entrez Gene 682 Human UniProt ID P35613
Background	CD147 (basigin, neurothelin, OX-47, 5A11, CE9, M6) also known as EMMPRIN (extracellular matrix metalloproteinase inducer) or TCSF (tumour cell-derived collagenase-stimulatory factor) is an ubiquitously expressed cell surface protein with multiple glycosylated forms. The highest level of CD147 expression is on metabolically active cells, such as lymphoblasts, inflammatory cells, brown adipocytes and malignant tumour cells. CD147 has multiple functions, including facilitating of cell surface expression of monocarboxylate transporter proteins and extracellular matrix metalloproteinases, regulation of integrin functions, it plays roles in cell development and activation, fetal development or retinal function.
Synonyms	Basigin, BSG, EMMPRIN, TCSF
Reference Data

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