CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: MEM-229]

Specifications

Product Data
Clone Name	MEM-229
Applications	FC, IF
Recommend Dilution	Indirect immunofluorescence analysis by Flow Cytometry.
Reactivity	Human, Porcine
Host	Mouse
Clonality	Monoclonal
Immunogen	Recombinant Vaccinia virus containing the Human CD105 (L-isoform) cDNA.
Specificity	This antibody recognizes CD105 (Endoglin), a 180 kDa type I integral membrane homodimer glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow; it is also present on syncytiotrophoblast on placenta throughout pregnancy.
Formulation	PBS, pH~7.4 with 0.2 % BSA Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM Sodium Azide Label: Conjugated with -LC-NHS under optimum conditions. The reagent is free of unconjugated biotin
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Gene Name	endoglin
Database Link	Entrez Gene 2022 Human UniProt ID P17813
Background	CD105 (Endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.
Synonyms	ENG, END, HHT1, ORW, ORW1
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Transmembrane

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