TSH beta (TSHB) Mouse Monoclonal Antibody [Clone ID: TSH-116]

Specifications

Product Data
Clone Name	TSH-116
Applications	ELISA, R
Recommend Dilution	ELISA. RIA. The antibody TSH-116 is suitable in combination with the antibody TSH-51 (AM03068PU-N) for Immunometric assays in the screening of neonatal hypothyroidism.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Human thyrotropin.
Specificity	The antibody TSH-116 reacts with human thyroid stimulating hormone (hTSH, thyrotropin), a glycoprotein hormone produced by the anterior pituitary gland cells in response to signals from the hypothalamus gland in the brain. The TSH-116 reacts with association constant 1.1 x 1011 l/mol. Following cross-reactivity expressed as binding of labelled hormone (% of total) was determined by solid phase RIA with excess of the antibody TSH-116: hTSH (78.9), hCG (20.3), hLH (23.2), hFSH (29.9).
Isotype	IgG2a
Formulation	PBS, pH 7.4 with 15 mM sodium azide as preservative. State: Aff - Purified State: Liquid purified IgG fraction (> 95% pure by SDS-PAGE).
Concentration	lot specific
Purification	Protein A affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	thyroid stimulating hormone beta
Database Link	Entrez Gene 7252 Human UniProt ID P01222
Background	Thyrotropin (hTSH) promotes the growth of the thyroid gland in the neck and stimulates it to produce more thyroid hormones. hTSH is composed of two subunits - alpha and beta.
Synonyms	Thyrotropin subunit beta, Thyroid-stimulating hormone subunit beta, TSH, TSHB, TSH beta
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Autoimmune thyroid disease, Neuroactive ligand-receptor interaction

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