ARAP1 Mouse Monoclonal Antibody [Clone ID: ARAP1-2]

Specifications

Product Data
Clone Name	ARAP1-2
Applications	IF, IP, WB
Recommend Dilution	Suitable for Western Blotting (2 μg/ml). Immunoprecipitation. Immunocytochemistry.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	His6-tagged protein corresponding to amino acids 1190-1450 of human ARAP1
Specificity	The antibody ARAP1-2 reacts with C-terminal part of ARAP1, a 160 kDa adaptor protein.
Isotype	IgG1
Formulation	PBS, pH 7.4 with 15 mM sodium azide as preservative. State: Aff - Purified State: Liquid purified Ig fraction (> 95% pure by SDS-PAGE)
Concentration	lot specific
Purification	Protein A affinity chromatography
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid freeze/thaw cycles.
Gene Name	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
Database Link	Entrez Gene 116985 Human UniProt ID Q96P48
Background	ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeate. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
Synonyms	KIAA0782, Centaurin-delta-2
Reference Data

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