HLA Class I ABC Mouse Monoclonal Antibody [Clone ID: W6/32]

Specifications

Product Data
Clone Name	W6/32
Applications	ELISA, FC, ICC, IHC, IP
Recommend Dilution	Flow Cytometry: (1/300 starting dilution). ELISA, IP, WB, IHC-Frozen sections, ICC: do be determined by user.
Reactivity	Bovine, Feline, Human, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Membrane of human tonsil cells
Specificity	The antibody W6/32 recognizes virtually all nucleated human cells. It is a valuable reagent for analysing variations in HLA class I expression in different disease states e.g. liver disease, muscular dystrophy, inflammatory myopathy and other neuromuscular disorders. This antibody W6/32 is also suitable as a positive control for HLA tissue typing and crossmatching.
Isotype	IgG2a
Formulation	PBS, pH~7.4 Label: Biotin State: Liquid purified Ig fraction Preservative: 15 mM Sodium Azide Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration	lot specific
Conjugation	Biotin
Storage Condition	Store undiluted at 2-8°C. DO NOT FREEZE!
Background	HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta-2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules. MHC Class I molecules (MHC Class Ia) are expressed on the surface of all human cell types.
Synonyms	MHC class I ABC, HLA Class 2 ABC
Reference Data

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