Complement Component 6 (C6) Mouse Monoclonal Antibody [Clone ID: 056B-214.2.4.2]

Specifications

Product Data
Clone Name	056B-214.2.4.2
Applications	ELISA, FC, IHC
Recommend Dilution	ELISA. Flow Cytometry. Immunohistochemistry on Frozen Sections. Recommended Positive Control: Kidney from post streptoccal glomerulonephritis patients.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified Human C6
Specificity	This antibody recognizes complement component 6 (C6). This antibody recognizes MAC.
Isotype	IgG1
Formulation	Borate buffered saline pH 8.2-8.4 containing 0.02% Sodium Azide as preservative State: Purified State: Liquid purified IgG fraction.
Concentration	lot specific
Purification	Affinity Chromatography on Protein A
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement component 6
Database Link	Entrez Gene 729 Human UniProt ID P13671
Background	C6 is a 104 kDa member of the complement C6/C7/C8/C9 family present in blood serum. The factor I modules of C6 bind the C terminus of the C5b alpha-chain, anchoring the molecule to the membrane and also binds complement component 7. This enables the formation of the C5b-7 precursor complex. C5b-7 then functions as a receptor for components C8 and C9 which form the complement membrane attack complex (MAC). Deficiency of C6 results in susceptibility to bacterial infection.
Synonyms	C6
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Complement and coagulation cascades, Prion diseases, Systemic lupus erythematosus

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