Il17a Rat Monoclonal Antibody [Clone ID: TC11-8H4]

Specifications

Product Data
Clone Name	TC11-8H4
Applications	ELISA
Recommend Dilution	ELISA.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	Recombinant mouse IL-17 expressed in E. coli
Specificity	This antibody recognises mouse Interleukin 17.
Isotype	IgG1
Formulation	Borate buffered saline, pH8.2 State: Purified State: Liquid purified Ig
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody in aliquots at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	interleukin 17A
Database Link	Entrez Gene 16171 Mouse UniProt ID Q62386
Background	Interleukin 17 is a 32kDa disulfide-linked homodimer consisting of two 136 amino acid chains, which belongs to the IL-17 family (classified as IL-17A to IL-17F), and signals through the IL-17 receptor (IL-17R/CDw217). IL-17 is produced primarily by activated CD4+ T cells and induces a variety of target cells to secrete inflammatory cytokines, including IL-1beta, IL-6, TNFalpha, IFNgamma and granulocyte colony-stimulating factor, as well as synergizing with other inflammatory cytokines and agonists. The role of IL-17 in bone metabolism has become a focus area for studies into Rheumatoid Arthritis, in which levels of IL-17 are significantly increased and may contribute to bone destruction.
Synonyms	IL-17A, IL17, IL-17, CTLA8, CTLA-8
Reference Data

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