CD88 / C5R1 Rat Monoclonal Antibody [Clone ID: 10/92]

Specifications

Product Data
Clone Name	10/92
Applications	FC, IHC
Recommend Dilution	Flow Cytometry: Use 10 µl of 1/50-1/100 diluted antibody to label 1x106 cells in 100 µl. Immunohistochemistry on Frozen Sections. This clone is reported to work in Immunohistochemistry on Paraffin Sections.
Reactivity	Mouse
Host	Rat
Clonality	Monoclonal
Immunogen	RBL-2H3 transfected cells expressing murine C5aR. Cells from immunised Lou/c rats were fused with cells of the X63-Ag8.653 myeloma cell line.
Specificity	This antibody Clone 10/92 recognizes Murine CD88. Clone 10/92 does not block the binding of the C5a to Murine CD88 (See Souri et al. 2003).
Isotype	IgG2a
Formulation	PBS, pH 7.4 containing 0.09% Sodium Azide State: Purified State: Liquid purified IgG fraction
Concentration	lot specific
Purification	Affinity Chromatography on Protein G
Conjugation	Unconjugated
Storage Condition	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing.
Gene Name	complement component 5a receptor 1
Database Link	Entrez Gene 12273 Mouse UniProt ID P30993
Background	CD88 is a 45kD G-protein coupled cell surface receptor, which is otherwise known as C5aR. The CD88 molecule functions as a receptor for the complement component C5a, which is a potent proinflammatory molecule and a chemoattractant for neutrophils to sites of infection. In mouse, CD88 is expressed on granulocytes, monocytes and macrophages but not on resting or stimulated lymphocytes.
Synonyms	C5a-R, C5aR, C5AR1, Complement Component 5a Receptor 1
Reference Data

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