CD1B Mouse Monoclonal Antibody [Clone ID: 100-1A5]

Specifications

Product Data
Clone Name	100-1A5
Applications	IF, IHC
Recommend Dilution	Flow Cytometry (1). Immunofluorescence. Immunohistochemistry on Frozen Sections Positive Control: Human lymphocytes.
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Stimulated Human leucocytes. Splenocytes were fused with mouse myeloma NS1 cells.
Specificity	100-1A5 binds with CD1b which is a 45 kD membrane glycoprotein expressed together with beta-2 Microglobulin. This antibody reacts with cortical thymocytes, Langerhans cells interdigitating cells and with pyramidal cells in the brain. It can be applied for characterization of leukemia's and lymphomas. Cellular Localization: Cell membrane and cytoplasm.
Isotype	IgM
Formulation	PBS State: Purified State: Liquid purified Ig fraction Preservative: 0.05% Sodium Azide
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Store the antibody undiluted at 2-8°C
Predicted Protein Size	45 kDa
Gene Name	CD1b molecule
Database Link	Entrez Gene 910 Human UniProt ID P29016
Background	CD1b which is associated with β2 microglobulin (1) is expressed on cortical thymocytes (moderate), Langerhans cells, interdigitating cells and brain pyramidal cells (1). It is up-regulated in peripheral neuropathy and inflammatory diseases (2,3). CD1b is the member of CD1 family. At least five CD1 genes (CD1a, b, c, d, and e) are identified (1). Unlike other members in CD1 family which have multiple splicing patterns, CD1b only revealed a single membrane RNA product (1). CD1 proteins including CD1b have been demonstrated to restrict T-cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation (4)
Synonyms	CD1; CD1A; MGC125990; MGC125991; R1
Reference Data

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