SIRT2 / SIR2 (1-352, His-tag) Human Protein
CAT#: AR09743PU-N
SIRT2 / SIR2 (1-352, His-tag) human recombinant protein, 50 µg
Size: 10 ug
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CNY 14,920.00
货期*
详询
规格
Cited in 5 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MGSSHHHHHH SSGLVPRGSH MDFLRNLFSQ TLSLGSQKER LLDELTLEGV ARYMQSERCR RVICLVGAGI STSAGIPDFR SPSTGLYDNL EKYHLPYPEA IFEISYFKKH PEPFFALAKE LYPGQFKPTI CHYFMRLLKD KGLLLRCYTQ NIDTLERIAG LEQEDLVEAH GTFYTSHCVS ASCRHEYPLS WMKEKIFSEV TPKCEDCQSL VKPDIVFFGE SLPARFFSCM QSDFLKVDLL LVMGTSLQVQ PFASLISKAP LSTPRLLINK EKAGQSDPFL GMIMGLGGGM DFDSKKAYRD VAWLGECDQG CLALAELLGW KKELEDLVRR EHASIDAQSG AGVPNPSTSA SPKKSPPPAK DEARTTEREK PQ
|
Tag | His-tag |
Predicted MW | 41.7 kDa |
Concentration | lot specific |
Purity | >90% |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol, 2 mM DTT, 200 mM NaCl, 0.5 mM EDTA |
Preparation | Liquid purified protein |
Protein Description | Recombinant human SIRT2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001180215 |
Locus ID | 22933 |
UniProt ID | Q8IXJ6, A0A0A0MRF5 |
Cytogenetics | 19q13.2 |
Synonyms | SIR2; SIR2L; SIR2L2 |
Summary | This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010] |
Protein Families | Druggable Genome, Transcription Factors |
Citations (5)
The use of this Proteins has been cited in the following citations: |
---|
Activation of toll like receptor 4 (TLR4) promotes cardiomyocyte apoptosis through SIRT2 dependent p53 deacetylation
,null,
Scientific Reports
,PubMed ID 33159115
[SIRT2]
|
Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer
,null,
Nucleic Acids Research
,PubMed ID 32112098
[SIRT2]
|
SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib
,null,
Cancers
,PubMed ID 31091806
[SIRT2]
|
Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency
,null,
Scientific Reports
,PubMed ID 29213065
[SIRT2]
|
SIRT2 inhibits non-small cell lung cancer cell growth through impairing Skp2-mediated p27 degradation
,null,
Oncotarget
,PubMed ID 26942878
[SIRT2]
|
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