RAB5A / RAB5 (1-215) Human Protein
CAT#: AR09078PU-L
RAB5A / RAB5 (1-215) human recombinant protein, 0.5 mg
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CNY 17,930.00
货期*
详询
规格
Cited in 4 publications. |
Specifications
Product Data | |
Species | Human |
Expression Host | E. coli |
Expression cDNA Clone or AA Sequence |
MASRGATRPN GPNTGNKICQ FKLVLLGESA VGKSSLVLRF VKGQFHEFQE STIGAAFLTQ TVCLDDTTVK FEIWDTAGQE RYHSLAPMYY RGAQAAIVVY DITNEESFAR AKNWVKELQR QASPNIVIAL SGNKADLANK RAVDFQEAQS YADDNSLLFM ETSAKTSMNV NEIFMAIAKK LPKNEPQNPG ANSARGRGVD LTEPTQPTRN QCCSN
|
Concentration | lot specific |
Purity | ≥95 by SDS-PAGE |
Buffer | Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris pH 8.0 |
Preparation | Liquid purified protein |
Protein Description | Recombinant human Rab5a was expressed in E.coli and purified by using conventional chromatography techniques. |
Storage | Store (in aliquots) at -20°C. Avoid repeated freezing and thawing. |
Stability | Shelf life: one year from despatch. |
Reference Data | |
RefSeq | NP_001278977 |
Locus ID | 5868 |
UniProt ID | P20339 |
Cytogenetics | 3p24.3 |
Synonyms | RAB5 |
Summary | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes (PubMed:10818110, PubMed:14617813, PubMed:16410077, PubMed:15378032). Contributes to the regulation of filopodia extension (PubMed:14978216). Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan (PubMed:22660413). Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3 (By similarity).[UniProtKB/Swiss-Prot Function] |
Protein Families | Druggable Genome |
Protein Pathways | Amyotrophic lateral sclerosis (ALS), Endocytosis |
Citations (4)
The use of this Proteins has been cited in the following citations: |
---|
Agonist-activated glucagon receptors are deubiquitinated at early endosomes by two distinct deubiquitinases to facilitate Rab4a-dependent recycling
,null,
The Journal of Biological Chemistry
,PubMed ID 32967969
[RAB5A]
|
Rab5a is overexpressed in oral cancer and promotes invasion through ERK/MMP signaling
,null,
Molecular Medicine Reports
,PubMed ID 28849149
[RAB5A]
|
Expression of Rab5a correlates with tumor progression in pancreatic carcinoma.
,null,
Virchows Archiv : an international journal of pathology
,PubMed ID 28243729
[RAB5A]
|
Overexpression of Rab5a promotes hepatocellular carcinoma cell proliferation and invasion via FAK signaling pathway
,null,
Tumor Biology
,PubMed ID 26443539
[RAB5A]
|
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