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FLT3 (NM_004119) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC211459L4V
- LentiORF®
-
Lenti ORF particles, FLT3 (mGFP-tagged) - Human fms-related tyrosine kinase 3 (FLT3), 200ul, >10^7 TU/mL
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CNY 9,975.00
货期*
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规格
| Cited in 1 publication. |
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Specifications
| Product Data | |
| Product Name | FLT3 (NM_004119) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | CD135; FLK-2; FLK2; STK1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_004119 |
| ORF Size | 2979 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC211459).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_004119.1 |
| RefSeq Size | 3475 bp |
| RefSeq ORF | 2982 bp |
| Locus ID | 2322 |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Protein Kinase, Transmembrane |
| Protein Pathways | Acute myeloid leukemia, Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Pathways in cancer |
| MW | 112.7 kDa |
| Gene Summary | This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Human Cytomegalovirus UL7, miR-US5-1, and miR-UL112-3p Inactivation of FOXO3a Protects CD34+ Hematopoietic Progenitor Cells from Apoptosis
,Hancock, MH;Crawford, LB;Perez, W;Struthers, HM;Mitchell, J;Caposio, P;,
mSphere
,PubMed ID 33408225
[FLT3]
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