MTHFD2 (NM_001040409) Human Tagged ORF Clone Lentiviral Particle
CAT#: RC203095L3V
- LentiORF®
Lenti ORF particles, MTHFD2 (Myc-DDK tagged) - Human methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2), nuclear gene encoding mitochondrial protein, tra, 200ul, >10^7 TU/mL
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CNY 7,410.00
货期*
详询
规格
Cited in 2 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Product Name | MTHFD2 (NM_001040409) Human Tagged ORF Clone Lentiviral Particle |
Synonyms | methylenetetrahydrofolate dehydro; methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase; methylene tetrahydrofolate dehydrogenase 2; NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase; NMDMC |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_001040409 |
ORF Size | 744 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(RC203095).
|
OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_001040409.1, NP_001035499.1 |
RefSeq Size | 2306 bp |
RefSeq ORF | 746 bp |
Locus ID | 10797 |
Protein Families | Druggable Genome |
Protein Pathways | Glyoxylate and dicarboxylate metabolism, Metabolic pathways, One carbon pool by folate |
MW | 26.8 kDa |
Gene Summary | This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009] |
Citations (2)
The use of this cDNA Clones has been cited in the following citations: |
---|
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines
,null,
OncoTargets and therapy
,PubMed ID 31496738
[MTHFD2]
|
High-throughput RNAi screening for novel modulators of vimentin expression identifies MTHFD2 as a regulator of breast cancer cell migration and invasion
,null,
Oncotarget
,PubMed ID 23295955
[MTHFD2]
|
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