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Nr1h3 (NM_013839) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR227522L4V
- LentiORF®
-
Lenti ORF particles, Nr1h3 (GFP-tagged) - Mouse nuclear receptor subfamily 1, group H, member 3 (Nr1h3), transcript variant 1, 200ul, >10^7 TU/mL
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CNY 9,975.00
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Specifications
| Product Data | |
| Product Name | Nr1h3 (NM_013839) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | AU018371; LXR; RLD1; Unr1 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_013839 |
| ORF Size | 1335 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR227522).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_013839.4, NP_038867.2 |
| RefSeq Size | 1955 bp |
| RefSeq ORF | 1338 bp |
| Locus ID | 22259 |
| Gene Summary | Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:18055760, PubMed:19520913, PubMed:20427281). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.[UniProtKB/Swiss-Prot Function] |
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